Publications

Articles From PubMed

Power KM, Nguyen KC, Silva A, Singh S, Hall DH, Rongo C, Barr MM. NEKL-4 regulates microtubule stability and mitochondrial health in ciliated neurons. J Cell Biol. 2024 Sep 2;223(9). doi: 10.1083/jcb.202402006. Epub 2024 May 20. PubMed PMID: 38767515; PubMed Central PMCID: PMC11104396.
Wang J, Saul J, Nikonorova IA, Cruz CN, Power KM, Nguyen KC, Hall DH, Barr MM. Ciliary intrinsic mechanisms regulate dynamic ciliary extracellular vesicle release from sensory neurons. Curr Biol. 2024 May 29;. doi: 10.1016/j.cub.2024.05.015. [Epub ahead of print] PubMed PMID: 38838665; NIHMSID:NIHMS1995373.
Nikonorova IA, desRanleau E, Jacobs KC, Saul J, Walsh JD, Wang J, Barr MM. Polycystins recruit cargo to distinct ciliary extracellular vesicle subtypes. bioRxiv. 2024 Apr 18;. doi: 10.1101/2024.04.17.588758. PubMed PMID: 38659811; PubMed Central PMCID: PMC11042387.
Power KM, Nguyen KC, Silva A, Singh S, Hall DH, Rongo C, Barr MM. NEKL-4 regulates microtubule stability and mitochondrial health in C. elegans ciliated neurons. bioRxiv. 2024 Feb 14;. doi: 10.1101/2024.02.14.580304. PubMed PMID: 38405845; PubMed Central PMCID: PMC10888866.
Akella JS, Silva MS, Nguyen KC, Hall DH, Barr MM. Cell-specific α-tubulin TBA-6 and pan-ciliary IFT cargo RAB-28 generate a non-canonical transition zone. bioRxiv. 2023 November.
Wang J, Saul J, Nikonorova IA, Cruz CN, Power KM, Nguyen KC, Hall DH, Barr MM. Ciliary intrinsic mechanisms regulate dynamic ciliary extracellular vesicle release from sensory neurons. bioRxiv. 2023 Nov 3;. doi: 10.1101/2023.11.01.565151. PubMed PMID: 37961114; PubMed Central PMCID: PMC10635059.
Walsh JD, Wang J, DeHart M, Nikonorova IA, Srinivasan J, Barr MM. Tracking N- and C-termini of C. elegans polycystin-1 reveals their distinct targeting requirements and functions in cilia and extracellular vesicles. PLoS Genet. 2022 Dec;18(12):e1010560. doi: 10.1371/journal.pgen.1010560. eCollection 2022 Dec. PubMed PMID: 36574451; PubMed Central PMCID: PMC9829181.
Nikonorova IA, Wang J, Cope AL, Tilton PE, Power KM, Walsh JD, Akella JS, Krauchunas AR, Shah P, Barr MM. Isolation, profiling, and tracking of extracellular vesicle cargo in Caenorhabditis elegans. Curr Biol. 2022 May 9;32(9):1924-1936.e6. doi: 10.1016/j.cub.2022.03.005. Epub 2022 Mar 24. PubMed PMID: 35334227; PubMed Central PMCID: PMC9491618.
Wang J, Nikonorova IA, Silva M, Walsh JD, Tilton PE, Gu A, Akella JS, Barr MM. Sensory cilia act as a specialized venue for regulated extracellular vesicle biogenesis and signaling. Curr Biol. 2021 Sep 13;31(17):3943-3951.e3. doi: 10.1016/j.cub.2021.06.040. Epub 2021 Jul 15. PubMed PMID: 34270950; PubMed Central PMCID: PMC8440419.
Akella JS, Barr MM. The tubulin code specializes neuronal cilia for extracellular vesicle release. Dev Neurobiol. 2021 Apr;81(3):231-252. doi: 10.1002/dneu.22787. Epub 2020 Nov 8. Review. PubMed PMID: 33068333; PubMed Central PMCID: PMC8052387.
Ramadan YH, Gu A, Ross N, McEwan SA, Barr MM, Firestein BL, O'Hagan R. CCP1, a Tubulin Deglutamylase, Increases Survival of Rodent Spinal Cord Neurons following Glutamate-Induced Excitotoxicity. eNeuro. 2021 Mar-Apr;8(2). doi: 10.1523/ENEURO.0431-20.2021. Print 2021 Mar-Apr. PubMed PMID: 33688040; PubMed Central PMCID: PMC8021396.
Power KM, Akella JS, Gu A, Walsh JD, Bellotti S, Morash M, Zhang W, Ramadan YH, Ross N, Golden A, Smith HE, Barr MM, O'Hagan R. Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function. PLoS Genet. 2020 Oct;16(10):e1009052. doi: 10.1371/journal.pgen.1009052. eCollection 2020 Oct. PubMed PMID: 33064774; PubMed Central PMCID: PMC7592914.
Walsh JD, Boivin O, Barr MM. What about the males? the C. elegans sexually dimorphic nervous system and a CRISPR-based tool to study males in a hermaphroditic species. J Neurogenet. 2020 Sep-Dec;34(3-4):323-334. doi: 10.1080/01677063.2020.1789978. Epub 2020 Jul 10. PubMed PMID: 32648491; PubMed Central PMCID: PMC7796903.
Wang J, Nikonorova IA, Gu A, Sternberg PW, Barr MM. Release and targeting of polycystin-2-carrying ciliary extracellular vesicles. Curr Biol. 2020 Jul 6;30(13):R755-R756. doi: 10.1016/j.cub.2020.05.079. PubMed PMID: 32634412; PubMed Central PMCID: PMC7668157.
Akella JS, Carter SP, Nguyen K, Tsiropoulou S, Moran AL, Silva M, Rizvi F, Kennedy BN, Hall DH, Barr MM, Blacque OE. Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding. Elife. 2020 Feb 26;9. doi: 10.7554/eLife.50580. PubMed PMID: 32101165; PubMed Central PMCID: PMC7043889.
Akella JS, Silva M, Morsci NS, Nguyen KC, Rice WJ, Hall DH, Barr MM. Cell type-specific structural plasticity of the ciliary transition zone in C. elegans. Biol Cell. 2019 Apr;111(4):95-107. doi: 10.1111/boc.201800042. Epub 2019 Feb 14. PubMed PMID: 30681171; PubMed Central PMCID: PMC6922583.
Wang J, Barr MM. Cell-cell communication via ciliary extracellular vesicles: clues from model systems. Essays Biochem. 2018 May 15;62(2):205-213. doi: 10.1042/EBC20170085. Print 2018 May 15. Review. PubMed PMID: 29717060; PubMed Central PMCID: PMC6922582.
Barr MM, García LR, Portman DS. Sexual Dimorphism and Sex Differences in Caenorhabditis elegans Neuronal Development and Behavior. Genetics. 2018 Mar;208(3):909-935. doi: 10.1534/genetics.117.300294. PubMed PMID: 29487147; PubMed Central PMCID: PMC5844341.
O'Hagan R, Silva M, Nguyen KCQ, Zhang W, Bellotti S, Ramadan YH, Hall DH, Barr MM. Glutamylation Regulates Transport, Specializes Function, and Sculpts the Structure of Cilia. Curr Biol. 2017 Nov 20;27(22):3430-3441.e6. doi: 10.1016/j.cub.2017.09.066. Epub 2017 Nov 9. PubMed PMID: 29129530; PubMed Central PMCID: PMC5698134.
Silva M, Morsci N, Nguyen KCQ, Rizvi A, Rongo C, Hall DH, Barr MM. Cell-Specific α-Tubulin Isotype Regulates Ciliary Microtubule Ultrastructure, Intraflagellar Transport, and Extracellular Vesicle Biology. Curr Biol. 2017 Apr 3;27(7):968-980. doi: 10.1016/j.cub.2017.02.039. Epub 2017 Mar 16. PubMed PMID: 28318980; PubMed Central PMCID: PMC5688951.
Lockhead D, Schwarz EM, O'Hagan R, Bellotti S, Krieg M, Barr MM, Dunn AR, Sternberg PW, Goodman MB. The tubulin repertoire of C. elegans sensory neurons and its context-dependent role in process outgrowth. Mol Biol Cell. 2016 Sep 21;27(23):3717-28. doi: 10.1091/mbc.E16-06-0473. [Epub ahead of print] PubMed PMID: 27654945; PubMed Central PMCID: PMC5170555.
Wang J, Barr MM. Ciliary Extracellular Vesicles: Txt Msg Organelles. Cell Mol Neurobiol. 2016 Apr;36(3):449-57. doi: 10.1007/s10571-016-0345-4. Epub 2016 Mar 17. Review. PubMed PMID: 26983828; PubMed Central PMCID: PMC4886304.
O'Hagan R, Barr MM. Kymographic Analysis of Transport in an Individual Neuronal Sensory Cilium in Caenorhabditis elegans. Methods Mol Biol. 2016;1454:107-22. doi: 10.1007/978-1-4939-3789-9_8. PubMed PMID: 27514919.
Wang J, Kaletsky R, Silva M, Williams A, Haas LA, Androwski RJ, Landis JN, Patrick C, Rashid A, Santiago-Martinez D, Gravato-Nobre M, Hodgkin J, Hall DH, Murphy CT, Barr MM. Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis. Curr Biol. 2015 Dec 21;25(24):3232-8. doi: 10.1016/j.cub.2015.10.057. Epub 2015 Dec 10. PubMed PMID: 26687621; PubMed Central PMCID: PMC4698341.
O'Hagan R, Barr MM. A motor relay on ciliary tracks. Nat Cell Biol. 2015 Dec;17(12):1517-9. doi: 10.1038/ncb3279. PubMed PMID: 26612573; PubMed Central PMCID: PMC4898050.
Langenhan T, Barr MM, Bruchas MR, Ewer J, Griffith LC, Maiellaro I, Taghert PH, White BH, Monk KR. Model Organisms in G Protein-Coupled Receptor Research. Mol Pharmacol. 2015 Sep;88(3):596-603. doi: 10.1124/mol.115.098764. Epub 2015 May 15. Review. PubMed PMID: 25979002; PubMed Central PMCID: PMC4551050.
Maguire JE, Silva M, Nguyen KC, Hellen E, Kern AD, Hall DH, Barr MM. Myristoylated CIL-7 regulates ciliary extracellular vesicle biogenesis. Mol Biol Cell. 2015 Aug 1;26(15):2823-32. doi: 10.1091/mbc.E15-01-0009. Epub 2015 Jun 3. PubMed PMID: 26041936; PubMed Central PMCID: PMC4571341.
Warburton-Pitt SR, Silva M, Nguyen KC, Hall DH, Barr MM. The nphp-2 and arl-13 genetic modules interact to regulate ciliogenesis and ciliary microtubule patterning in C. elegans. PLoS Genet. 2014 Dec;10(12):e1004866. doi: 10.1371/journal.pgen.1004866. eCollection 2014 Dec. PubMed PMID: 25501555; PubMed Central PMCID: PMC4263411.
Rajendran L, Bali J, Barr MM, Court FA, Krämer-Albers EM, Picou F, Raposo G, van der Vos KE, van Niel G, Wang J, Breakefield XO. Emerging roles of extracellular vesicles in the nervous system. J Neurosci. 2014 Nov 12;34(46):15482-9. doi: 10.1523/JNEUROSCI.3258-14.2014. Review. PubMed PMID: 25392515; PubMed Central PMCID: PMC4228143.
Barr MM. C. elegans male mating behavior. Introduction. Semin Cell Dev Biol. 2014 Sep;33:1-2. doi: 10.1016/j.semcdb.2014.06.006. Epub 2014 Jun 12. PubMed PMID: 24930770; PubMed Central PMCID: PMC4698983.
O'Hagan R, Wang J, Barr MM. Mating behavior, male sensory cilia, and polycystins in Caenorhabditis elegans. Semin Cell Dev Biol. 2014 Sep;33:25-33. doi: 10.1016/j.semcdb.2014.06.001. Epub 2014 Jun 27. Review. PubMed PMID: 24977333; PubMed Central PMCID: PMC4680976.
Sengupta P, Barr MM. New insights into an old organelle: meeting report on biology of cilia and flagella. Traffic. 2014 Jun;15(6):717-26. doi: 10.1111/tra.12166. Epub 2014 Mar 29. PubMed PMID: 24612344; PubMed Central PMCID: PMC4028063.
Silva M, Barr MM. Tomography gives a new dimension to an ancient organelle. Elife. 2014 Mar 25;3:e02589. doi: 10.7554/eLife.02589. PubMed PMID: 24668175; PubMed Central PMCID: PMC3965212.
Wang J, Silva M, Haas LA, Morsci NS, Nguyen KC, Hall DH, Barr MM. C. elegans ciliated sensory neurons release extracellular vesicles that function in animal communication. Curr Biol. 2014 Mar 3;24(5):519-25. doi: 10.1016/j.cub.2014.01.002. Epub 2014 Feb 13. PubMed PMID: 24530063; PubMed Central PMCID: PMC4659354.
Schroeder NE, Androwski RJ, Rashid A, Lee H, Lee J, Barr MM. Dauer-specific dendrite arborization in C. elegans is regulated by KPC-1/Furin. Curr Biol. 2013 Aug 19;23(16):1527-35. doi: 10.1016/j.cub.2013.06.058. Epub 2013 Aug 8. PubMed PMID: 23932402; PubMed Central PMCID: PMC4671503.
Barrios A, Ghosh R, Fang C, Emmons SW, Barr MM. PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans. Nat Neurosci. 2012 Dec;15(12):1675-82. doi: 10.1038/nn.3253. Epub 2012 Nov 11. PubMed PMID: 23143519; PubMed Central PMCID: PMC3509246.
Warburton-Pitt SR, Jauregui AR, Li C, Wang J, Leroux MR, Barr MM. Ciliogenesis in Caenorhabditis elegans requires genetic interactions between ciliary middle segment localized NPHP-2 (inversin) and transition zone-associated proteins. J Cell Sci. 2012 Jun 1;125(Pt 11):2592-603. doi: 10.1242/jcs.095539. Epub 2012 Mar 5. PubMed PMID: 22393243; PubMed Central PMCID: PMC3403231.
Morsci NS, Haas LA, Barr MM. Sperm status regulates sexual attraction in Caenorhabditis elegans. Genetics. 2011 Dec;189(4):1341-6. doi: 10.1534/genetics.111.133603. Epub 2011 Oct 3. PubMed PMID: 21968192; PubMed Central PMCID: PMC3241412.
O'Hagan R, Piasecki BP, Silva M, Phirke P, Nguyen KC, Hall DH, Swoboda P, Barr MM. The tubulin deglutamylase CCPP-1 regulates the function and stability of sensory cilia in C. elegans. Curr Biol. 2011 Oct 25;21(20):1685-94. doi: 10.1016/j.cub.2011.08.049. Epub 2011 Oct 6. PubMed PMID: 21982591; PubMed Central PMCID: PMC4680987.
Morsci NS, Barr MM. Kinesin-3 KLP-6 regulates intraflagellar transport in male-specific cilia of Caenorhabditis elegans. Curr Biol. 2011 Jul 26;21(14):1239-44. doi: 10.1016/j.cub.2011.06.027. Epub 2011 Jul 14. PubMed PMID: 21757353; PubMed Central PMCID: PMC3143291.
Wang J, Schwartz HT, Barr MM. Functional specialization of sensory cilia by an RFX transcription factor isoform. Genetics. 2010 Dec;186(4):1295-307. doi: 10.1534/genetics.110.122879. Epub 2010 Oct 5. PubMed PMID: 20923979; PubMed Central PMCID: PMC2998312.
Bae YK, Kim E, L'hernault SW, Barr MM. The CIL-1 PI 5-phosphatase localizes TRP Polycystins to cilia and activates sperm in C. elegans. Curr Biol. 2009 Oct 13;19(19):1599-607. doi: 10.1016/j.cub.2009.08.045. Epub 2009 Sep 24. PubMed PMID: 19781942; PubMed Central PMCID: PMC2762383.
Muley PD, McNeill EM, Marzinke MA, Knobel KM, Barr MM, Clagett-Dame M. The atRA-responsive gene neuron navigator 2 functions in neurite outgrowth and axonal elongation. Dev Neurobiol. 2008 Nov;68(13):1441-53. doi: 10.1002/dneu.20670. PubMed PMID: 18726912; PubMed Central PMCID: PMC4409142.
Bae YK, Lyman-Gingerich J, Barr MM, Knobel KM. Identification of genes involved in the ciliary trafficking of C. elegans PKD-2. Dev Dyn. 2008 Aug;237(8):2021-9. doi: 10.1002/dvdy.21531. PubMed PMID: 18407554; PubMed Central PMCID: PMC3118579.
Bae YK, Barr MM. Sensory roles of neuronal cilia: cilia development, morphogenesis, and function in C. elegans. Front Biosci. 2008 May 1;13:5959-74. doi: 10.2741/3129. Review. PubMed PMID: 18508635; PubMed Central PMCID: PMC3124812.
Jauregui AR, Nguyen KC, Hall DH, Barr MM. The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure. J Cell Biol. 2008 Mar 10;180(5):973-88. doi: 10.1083/jcb.200707090. Epub 2008 Mar 3. PubMed PMID: 18316409; PubMed Central PMCID: PMC2265406.
Knobel KM, Peden EM, Barr MM. Distinct protein domains regulate ciliary targeting and function of C. elegans PKD-2. Exp Cell Res. 2008 Feb 15;314(4):825-33. doi: 10.1016/j.yexcr.2007.10.017. Epub 2007 Nov 1. PubMed PMID: 18037411; PubMed Central PMCID: PMC2275051.
Hu J, Wittekind SG, Barr MM. STAM and Hrs down-regulate ciliary TRP receptors. Mol Biol Cell. 2007 Sep;18(9):3277-89. doi: 10.1091/mbc.e07-03-0239. Epub 2007 Jun 20. PubMed PMID: 17581863; PubMed Central PMCID: PMC1951776.
Liu T, Kim K, Li C, Barr MM. FMRFamide-like neuropeptides and mechanosensory touch receptor neurons regulate male sexual turning behavior in Caenorhabditis elegans. J Neurosci. 2007 Jul 4;27(27):7174-82. doi: 10.1523/JNEUROSCI.1405-07.2007. PubMed PMID: 17611271; PubMed Central PMCID: PMC6794584.
Bae YK, Qin H, Knobel KM, Hu J, Rosenbaum JL, Barr MM. General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia. Development. 2006 Oct;133(19):3859-70. doi: 10.1242/dev.02555. Epub 2006 Aug 30. PubMed PMID: 16943275.

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