In the free-living nematode Caenorhabditis elegans, cilia are found on the dendritic endings ... More > Sexual behaviors are evoked by a wide variety of sensory cues and generated by specialized sensory neurons ... More > Several human genetic disorders, including autosomal dominant polycystic kidney disease ... More >

The Barr lab uses the nematode C. elegans to study fundamental questions in biology (ciliogenesis, ciliary transport, and most recently, ciliary extracellular vesicles) and to model human genetic diseases of cilia. Using the beautiful simplicity of “the worm,” we consistently tackle major important problems that are biomedically relevant, and have a track record of groundbreaking discoveries. Many of the genes and pathways we study control C. elegans behaviors, therefore we are also interested in neurogenetics and neuroplasticity. Our studies have guided research into autosomal polycystic kidney disease and other ciliopathies. Our research has unlocked insights into three exciting new areas in the Barr lab: ciliary specialization, extracellular vesicles (EVs), and stress-induced neuronal restructuring.




January 2018

Barr lab is looking for new postdocs who are brilliant, motivated, and fearless at the bench!

We landed a new NIH grant on Nephronophthisis-related ciliopathies and ciliary compartmentalization.

Juan Wang received a grant from the NIH-funded Kansas PKD Center.

Bob O’Hagan published a Current Biology paper on tubulin modifying enzymes that regulate the structure and function of EV-releasing cilia.

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