In the free-living nematode Caenorhabditis elegans, cilia are found on the dendritic endings ... More > Sexual behaviors are evoked by a wide variety of sensory cues and generated by specialized sensory neurons ... More > Several human genetic disorders, including autosomal dominant polycystic kidney disease ... More >

The Barr lab uses the nematode C. elegans to study fundamental questions in biology (ciliogenesis, ciliary transport, and most recently, ciliary extracellular vesicles) and to model human genetic diseases of cilia. Using the beautiful simplicity of “the worm,” we consistently tackle major important problems that are biomedically relevant, and have a track record of groundbreaking discoveries. Many of the genes and pathways we study control C. elegans behaviors, therefore we are also interested in neurogenetics and neuroplasticity. Our studies have guided research into autosomal polycystic kidney disease and other ciliopathies. Our research has unlocked insights into three exciting new areas in the Barr lab: ciliary specialization, extracellular vesicles (EVs), and stress-induced neuronal restructuring.



May 2017

Juan Wang will present a talk on “Social Extracellular Vesicles” at the International C. elegans Conference at UCLA.

 Bon voyage to Malan Silva, who is heading off to his postdoc in the Jorgensen lab at Utah!

April 2017

The Barr lab welcomes new graduate student Kumar Tiger!!

Malan Silva spectacularly defended his Ph.D. dissertation. Congratulations Dr. Silva

Malan Silva’s paper was published in Current Biology. In collaboration with Hall (AECOM) and Rongo (Rutgers) laboratory, Malan discovered that a cell-specific tubulin isotype sculpts ciliary microtubules, controls intraflagellar transport, and regulates extracellular vesicle bioactivity.

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