|In the free-living nematode Caenorhabditis elegans, cilia are found on the dendritic endings ... More >||Sexual behaviors are evoked by a wide variety of sensory cues and generated by specialized sensory neurons ... More >||Several human genetic disorders, including autosomal dominant polycystic kidney disease ... More >|
The Barr lab uses the nematode C. elegans to study
fundamental questions in biology (ciliogenesis, ciliary transport,
and most recently, ciliary extracellular vesicles) and to model
human genetic diseases of cilia. Using the beautiful simplicity of
“the worm,” we consistently tackle major important problems that are
biomedically relevant, and have a track record of groundbreaking
discoveries. Many of the genes and pathways we study control C.
elegans behaviors, therefore we are also interested in neurogenetics
and neuroplasticity. Our studies have guided research into autosomal
polycystic kidney disease and other ciliopathies. Our research has
unlocked insights into three exciting new areas in the Barr lab:
ciliary specialization, extracellular vesicles (EVs), and
stress-induced neuronal restructuring.
We are obsessed about ciliary extracellular vesicles!
Juan and Maureen wrote a review on Ciliary Extracellular Vesicles: Txt Msg Organelles.
See also Juan’s paper on defining the molecular signature of extracellular vesicle releasing neurons in Current Biology. This work was initiated during Maureen’s sabbatical in the lab of Coleen Murphy at Princeton, our collaborators.
Copyright 2015 Barr Lab